25. MEN-4
MEN-4 features are similar to MEN-1.Associated with CDKN1B mutations leading to reduced levels of cell cycle checkpoint protein p27.
MEN-4 features are similar to MEN-1.Associated with CDKN1B mutations leading to reduced levels of cell cycle checkpoint protein p27.
It affects children under the age of 6 years old with severe disease often associated with children under 1 year old. Diagnostic criteria:. 5-day fever PLUS four of the following…➔ Bilateral conjunctivitis➔ Cervical lymph node >1.5cm➔ Polymorphous exanthem➔ Cracked lips/strawberry tongue➔ Erythema/oedema/peeling of the hands/feetOther features include BCG scar inflammation, raised CRP, thrombocytosis and irritability without CNS infection.Beware:. diagnosis can be made before Day 5 of fever if clinical signs suggestive. Also if just 2-3 criteria present, consider incomplete Kawasaki. Complications include:.● Coronary aneurysms (causing thrombosis, MI and tamponade)● Myocarditis● Bleeding (due to aspirin) Consider echo EARLY in diagnosis Treatment is with high-dose aspirin, IV immunoglobulin & Proton Pump Inhibitors.
Hello PG aspirants !, Just wanted to clarify a few things regarding the Q_Q_Bank on the SSM App. There is NO "Hidden agenda" or"Fine print" from my side. My main aim has to make a very useful, affordable and reliable Q Bank that can be used by all for practising recent MCQs, clinical MCQs and at the same time these MCQs will be ideal for revision. Whatever online platform or App or coaching class or notes, that you are using, this Q-Q Bank will add-on to your preparation. It is NOT meant to change / replace / disturb any of your preparation sources in any way (especially at this crucial time when exam is getting near). What I mean is even if you solving MCQs from any online App in their own QBank, My Q_Q_Bank will add on to your preparation by providing one more platform/opportunity to solve MCQs (as we all know information gets reinforced while solving MCQs.) Some points to note Subjectwise MCQs - 3-4 subjects (Physio, Biochem Medicine, Micro) are pending; Others are very much complete. Will finish BMicro and Bicohem by Augsut 30th; And the other two subjects Sept 30th.Clinical MCQs - 400 MCQs of the actual "new" exam pattern available. These are NOT very "high level" to check your clinical practice/ICU/Wards IQ - rather these are ideal from NEET PG point of view. I will try to increase this to at least 600-700 Clinical MCQs by November.JIPMER Junction: The previous 5 sessions of JIPMER papers are available on the QQ bank (with explanations) - this also includes the recent June 2020 paper. Also includes few JIPMER mock tests. Regarding Explanations: Explanations are available for All clinical MCQs and JIPMER previous papers. The Subjectwise MCQs do NOT have any explanations. Ideally these are best used after reading any topic. For example - solve Psoriasis MCQs after studyng that topic or solve "Esophagus MCQs" after studying esophagus in surgery or solve "Endometriosis MCQs" after studying that topic. That way the Q-Q-Bank lives up to its name of being a "Quick Q Bank" - You read and topic/subject and by doing MCQs you are revising the topic since the information gets reinforced while doing MCQs.Validity; The QQ Bank is valid till the NEET PG gets over in January. It is NOT a 1-year subscription I have already mentioned this on the opening "Buy Now" page also (like I said - NO fine print here). Please understand that extending this to 12 month validity will increase the cost due to the App platform used (rather I want to keep the cost affordable itself).Number of attempts/retakes: Multiple attempts ARE allowed. No limit currently. Bookmarking facility: It IS Available. When you are viewing the solutions of any module - just look at the top right corner - the bookmark symbol is there. You can organise the bookmarks into various folders also.Commenting for errors: Although errors are very few, it is possible that errors can creep in when compiling hundreds and thousands of questions. (In fact that is why even popular online Apps have the 'revised' tag above few MCQs and they are also bringing out newletters with MCQ Ids to clarify the updates etc). In my App - Commenting IS Available. When you are viewing the solutions of any module, if you find an error - you can comment below the question. I shall see and rectify/clarify soon.Any other add-ons ?: If time permits, I shall upload a few mock test towards November- December for NEET PG. Can I use this Q_Q_Bank without SSM book also? - Yes, it is NOT based on the book only. rather it is based on all recent MCQs, recent topics and subject theory knowledge of all subjects. So go ahead without any second thought - Use it - it WILL definitely help you guys.Can I use this for FMGE - YES! - Syllabus does NOT change for FMGE - so it will be useful, go ahead.And of course - There is NO Outsourcing (I have NOT employed few students/toppers to prepare this MCQ Bank - Just like my SSM book, Its fully my own effort here; (not to be disrespectful of anyone but we all know that most popular and upcoming new Q banks are "prepared by toppers/students" and only "Reviewed" by faculty - thats just for your info - some mention it openly, some put it in the "fine print - anyways thats ok) For anything further - you can comment below or message me on FB Messenger @ Ramgopal Balu All the Best Dr Ramgopal
Indications for anti- VEGFs Wet ARMD (choroidal neovascular membrane, CNVM) Diabetic retinopathy (for macular edema) Retinal Venous occlusive disease (for macular edema) Examples of anti-VEGFs are: Pegaptanib sodium; Bevacizumab, Ranibizumab, Aflibercept
Part of the body Occupational Exposure in Radiation workers General Public Exposure Whole body (Effective dose) Cumulative: 20 mSv/year averaged over 5 consecutive years; Annual: 30 mSv in any single year 1 mSv/yr Lens of eyes (Equivalent dose) 150 mSv/yr (15 rem) 15 mSv/yr (15 rem) Skin and Extremities (i.e, Hands and Feet) (Equivalent dose) 500 mSv/yr (50 rem) 50 mSv/yr (5 rem) During pregnancy, MPD is 5 mSv (0.5 rem) and should not excees 0.5 mSv (0.5 rem) in any single monthFor pregnant radiation workers, after declaration of pregnancy 1 mSv (0.1 rem) on the embryo/fetus should not be exceededSource: https://www.aerb.gov.in/english/radiation-protection-principle
Interstitial keratitisHutchinson's teeth (notched permanent incisors)Eight nerve (sensorineural) deafness
Whats New ? C4c - Corona PhlebectasiaC2r - Recurrent Varicose VeinsC6r - Recurrent Active Venous Ulcer
RIPRETENIBRipretenib is a kinase inhibitor indicated for the treatment of adult patients with advanced gastrointestinal stromal tumor (GIST) who have received prior treatment with 3 or more kinase inhibitors, including imatinib.Caution/Adverse effects: palmo-plantar erythrodysesthesia; impaired wound healing; cardiac dysfunction, HTN; New skin malignancy, teratogenicAVAPRITINIBAvapritinib is a kinase inhibitor indicated for the treatment of adults with unresectable or metastatic gastrointestinal stromal tumor (GIST) harboring a platelet-derived growth factor receptor alpha (PDGFRA) exon 18 mutation, including PDGFRA D842V mutationsCaution/Adverse effects: Intracranial hemorrhage; CNS effects (confusion, mood disturbance, sleep problems, hallucinations etc); teratogenic